MAP kinase signalling cascade in Arabidopsis innate immunity

Tsuneaki Asai, Guillaume Tena, Joulia Plotnikova, Matthew R. Willmann, Wan-Ling Chiu, Lourdes Gomez-Gomez, Thomas Boller, Frederick M. Ausubel and Jen Sheen ()
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Tsuneaki Asai: Harvard Medical School, Massachusetts General Hospital
Guillaume Tena: Harvard Medical School, Massachusetts General Hospital
Joulia Plotnikova: Harvard Medical School, Massachusetts General Hospital
Matthew R. Willmann: Harvard Medical School, Massachusetts General Hospital
Wan-Ling Chiu: Harvard Medical School, Massachusetts General Hospital
Lourdes Gomez-Gomez: Instituto de Desarrollo Regional, Sección de Biotecnología, Campus Universitario s/n
Thomas Boller: Friedrich Miescher-Institute
Frederick M. Ausubel: Harvard Medical School, Massachusetts General Hospital
Jen Sheen: Harvard Medical School, Massachusetts General Hospital

Nature, 2002, vol. 415, issue 6875, 977-983

Abstract: Abstract There is remarkable conservation in the recognition of pathogen-associated molecular patterns (PAMPs) by innate immune responses of plants, insects and mammals. We developed an Arabidopsis thaliana leaf cell system based on the induction of early-defence gene transcription by flagellin, a highly conserved component of bacterial flagella that functions as a PAMP in plants and mammals. Here we identify a complete plant MAP kinase cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) and WRKY22/WRKY29 transcription factors that function downstream of the flagellin receptor FLS2, a leucine-rich-repeat (LRR) receptor kinase. Activation of this MAPK cascade confers resistance to both bacterial and fungal pathogens, suggesting that signalling events initiated by diverse pathogens converge into a conserved MAPK cascade.

Date: 2002
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DOI: 10.1038/415977a

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