Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

Naohiro Terada (), Takashi Hamazaki, Masahiro Oka, Masanori Hoki, Diana M. Mastalerz, Yuka Nakano, Edwin M. Meyer, Laurence Morel, Bryon E. Petersen and Edward W. Scott
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Naohiro Terada: University of Florida College of Medicine
Takashi Hamazaki: University of Florida College of Medicine
Masahiro Oka: University of Florida College of Medicine
Masanori Hoki: University of Florida College of Medicine
Diana M. Mastalerz: University of Florida College of Medicine
Yuka Nakano: University of Florida College of Medicine
Edwin M. Meyer: University of Florida College of Medicine
Laurence Morel: University of Florida College of Medicine
Bryon E. Petersen: University of Florida College of Medicine
Edward W. Scott: University of Florida College of Medicine

Nature, 2002, vol. 416, issue 6880, 542-545

Abstract: Abstract Recent studies have demonstrated that transplanted bone marrow cells can turn into unexpected lineages including myocytes, hepatocytes, neurons and many others1. A potential problem, however, is that reports discussing such ‘transdifferentiation’ in vivo tend to conclude donor origin of transdifferentiated cells on the basis of the existence of donor-specific genes such as Y-chromosome markers1. Here we demonstrate that mouse bone marrow cells can fuse spontaneously with embryonic stem cells in culture in vitro that contains interleukin-3. Moreover, spontaneously fused bone marrow cells can subsequently adopt the phenotype of the recipient cells, which, without detailed genetic analysis, might be interpreted as ‘dedifferentiation’ or transdifferentiation.

Date: 2002
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DOI: 10.1038/nature730

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