Dominant role of the niche in melanocyte stem-cell fate determination

Emi K. Nishimura, Siobhán A. Jordan, Hideo Oshima, Hisahiro Yoshida, Masatake Osawa, Mariko Moriyama, Ian J. Jackson, Yann Barrandon, Yoshiki Miyachi and Shin-Ichi Nishikawa ()
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Emi K. Nishimura: Kyoto University
Siobhán A. Jordan: Western General Hospital
Hideo Oshima: Ecole Nomale Supérieure
Masatake Osawa: Riken Center for Developmental Biology
Mariko Moriyama: Riken Center for Developmental Biology
Ian J. Jackson: Western General Hospital
Yann Barrandon: Ecole Nomale Supérieure
Yoshiki Miyachi: Kyoto University
Shin-Ichi Nishikawa: Riken Center for Developmental Biology

Nature, 2002, vol. 416, issue 6883, 854-860

Abstract: Abstract Stem cells—which have the capacity to self-renew and generate differentiated progeny—are thought to be maintained in a specific environment known as a niche1,2,3. The localization of the niche, however, remains largely obscure for most stem-cell systems. Melanocytes (pigment cells) in hair follicles proliferate and differentiate closely coupled to the hair regeneration cycle4. Here we report that stem cells of the melanocyte lineage can be identified, using Dct-lacZ transgenic mice5,6, in the lower permanent portion of mouse hair follicles throughout the hair cycle. It is only the population in this region that fulfils the criteria for stem cells, being immature, slow cycling, self-maintaining and fully competent in regenerating progeny on activation at early anagen (the growing phase of hair follicles). Induction of the re-pigmentation process in K14-steel factor transgenic mice7 demonstrates that a portion of amplifying stem-cell progeny can migrate out from the niche and retain sufficient self-renewing capability to function as stem cells after repopulation into vacant niches. Our data indicate that the niche has a dominant role in the fate determination of melanocyte stem-cell progeny.

Date: 2002
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DOI: 10.1038/416854a

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