Chemokine-receptor genes and AIDS risk

Patricia A. Ramaley, Neil French, Pontiano Kaleebu, Charles Gilks, James Whitworth and Adrian V. S. Hill ()
Additional contact information
Patricia A. Ramaley: Wellcome Trust Centre for Human Genetics, University of Oxford
Neil French: Liverpool School of Tropical Medicine
Pontiano Kaleebu: Uganda Virus Research Institute/Medical Research Council (UK) Programme on HIV/AIDS
Charles Gilks: Liverpool School of Tropical Medicine
James Whitworth: Uganda Virus Research Institute/Medical Research Council (UK) Programme on HIV/AIDS
Adrian V. S. Hill: Wellcome Trust Centre for Human Genetics, University of Oxford

Nature, 2002, vol. 417, issue 6885, 140-140

Abstract: Abstract Schliekelman et al.1 have provided a model to quantify the speed at which HIV-resistance haplotypes can become enriched in a susceptible population through a delay in the onset of AIDS, permitting greater lifetime reproduction and the selection of AIDS-delaying haplotypes. But we question their conclusion1 that there could be a rapid evolution of resistance to AIDS onset in some African populations if the current HIV epidemic persists, as this depends on an untested assumption: that variant forms of the chemokine-receptor-5 (CCR5) gene impart selective advantages or disadvantages in Africa that are comparable to those reported for African Americans2,3,4,5,6. Here we test this premise in a large Ugandan population, and find that CCR5 variants are not associated with HIV/AIDS disease risk in Africa — the origin and centre of the current AIDS pandemic. This gene may therefore not be subject to rapid evolutionary change as a result of the HIV epidemic in Africa.

Date: 2002
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/417140a Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:417:y:2002:i:6885:d:10.1038_417140a

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/417140a

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().