Microtubule basis for left-handed helical growth in Arabidopsis

Siripong Thitamadee, Kazuko Tuchihara and Takashi Hashimoto ()
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Siripong Thitamadee: Nara Institute of Science and Technology
Kazuko Tuchihara: Nara Institute of Science and Technology
Takashi Hashimoto: Nara Institute of Science and Technology

Nature, 2002, vol. 417, issue 6885, 193-196

Abstract: Abstract Left–right asymmetry in plants can be found in helices of stalks, stems and tendrils, and in fan-like petal arrangements. The handedness in these asymmetric structures is often fixed in given species, indicating that genetic factors control asymmetric development1. Here we show that dominant negative mutations at the tubulin intradimer interface of α-tubulins 4 and 6 cause left-handed helical growth and clockwise twisting in elongating organs of Arabidopsis thaliana. We demonstrate that the mutant tubulins incorporate into microtubule polymers, producing right-handed obliquely oriented cortical arrays, in the root epidermal cells. The cortical microtubules in the mutants had increased sensitivity to microtubule-specific drugs. These results suggest that reduced microtubule stability can produce left-handed helical growth in plants.

Date: 2002
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DOI: 10.1038/417193a

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