GroEL buffers against deleterious mutations

Mario A. Fares, Mario X. Ruiz-González, Andrés Moya, Santiago F. Elena and Eladio Barrio ()
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Mario A. Fares: Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Departament de Genètica, Universitat de València
Mario X. Ruiz-González: Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Departament de Genètica, Universitat de València
Andrés Moya: Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Departament de Genètica, Universitat de València
Santiago F. Elena: Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Departament de Genètica, Universitat de València
Eladio Barrio: Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Departament de Genètica, Universitat de València

Nature, 2002, vol. 417, issue 6887, 398-398

Abstract: Abstract GroEL, a heat-shock protein that acts as a molecular chaperone1, is overproduced in endosymbiotic but not in free-living bacteria2,3,4, presumably to assist in the folding of conformationally damaged proteins. Here we show that the overproduction of GroEL in Escherichia coli masks the effects of harmful mutations that have accumulated during a simulated process of vertical transmission. This molecular mechanism, which may be an adaptation to the bacterium's intracellular lifestyle, is able to rescue lineages from a progressive fitness decline resulting from the fixation of deleterious mutations under strong genetic drift5,6.

Date: 2002
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DOI: 10.1038/417398a

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