Retraction Note: Directed evolution of new catalytic activity using the α/β-barrel scaffold

M. M. Altamirano, J. M. Blackburn, C. Aguayo and A. R. Fersht

Nature, 2002, vol. 417, issue 6887, 468-468

Abstract: Nature 403, 617–622 (2000). This laboratory reported the in vitro evolution of an enzyme with phosphoribosyl anthranilate isomerase activity (ivePRAI) from the α/β-barrel scaffold of indole-3-glycerol-phosphate synthase using a combination of rationally designed libraries, DNA shuffling, and selection with Escherichia coli, JA300, a strain that lacks an active PRAI gene.

Date: 2002
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DOI: 10.1038/417468a

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