Comparative assessment of large-scale data sets of protein–protein interactions

Christian von Mering, Roland Krause, Berend Snel, Michael Cornell, Stephen G. Oliver, Stanley Fields and Peer Bork ()
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Christian von Mering: European Molecular Biology Laboratory
Roland Krause: Cellzome AG
Berend Snel: European Molecular Biology Laboratory
Michael Cornell: University of Manchester
Stephen G. Oliver: University of Manchester
Stanley Fields: University of Washington
Peer Bork: European Molecular Biology Laboratory

Nature, 2002, vol. 417, issue 6887, 399-403

Abstract: Abstract Comprehensive protein–protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions.

Date: 2002
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DOI: 10.1038/nature750

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