Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells

Kenneth D. Harris, Darrell A. Henze, Hajime Hirase, Xavier Leinekugel, George Dragoi, Andras Czurkó and György Buzsáki ()
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Kenneth D. Harris: The State University of New Jersey
Darrell A. Henze: The State University of New Jersey
Hajime Hirase: The State University of New Jersey
Xavier Leinekugel: The State University of New Jersey
George Dragoi: The State University of New Jersey
Andras Czurkó: The State University of New Jersey
György Buzsáki: The State University of New Jersey

Nature, 2002, vol. 417, issue 6890, 738-741

Abstract: Abstract According to the temporal coding hypothesis1, neurons encode information by the exact timing of spikes. An example of temporal coding is the hippocampal phase precession phenomenon, in which the timing of pyramidal cell spikes relative to the theta rhythm shows a unidirectional forward precession during spatial behaviour2,3. Here we show that phase precession occurs in both spatial and non-spatial behaviours. We found that spike phase correlated with instantaneous discharge rate, and precessed unidirectionally at high rates, regardless of behaviour. The spatial phase precession phenomenon is therefore a manifestation of a more fundamental principle governing the timing of pyramidal cell discharge. We suggest that intrinsic properties of pyramidal cells have a key role in determining spike times, and that the interplay between the magnitude of dendritic excitation and rhythmic inhibition of the somatic region is responsible for the phase assignment of spikes4,5.

Date: 2002
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DOI: 10.1038/nature00808

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