Early-pregnancy origins of low birth weight

Gordon C. S. Smith (), Emily J. Stenhouse, Jennifer A. Crossley, David A. Aitken, Alan D. Cameron and J. Michael Connor
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Gordon C. S. Smith: University of Cambridge, The Rosie Hospital
Emily J. Stenhouse: The Queen Mother's Hospital
Jennifer A. Crossley: Institute of Medical Genetics, Yorkhill NHS Trust
David A. Aitken: Institute of Medical Genetics, Yorkhill NHS Trust
Alan D. Cameron: The Queen Mother's Hospital
J. Michael Connor: Institute of Medical Genetics, Yorkhill NHS Trust

Nature, 2002, vol. 417, issue 6892, 916-916

Abstract: Abstract Low birth weight is a significant cause of morbidity and mortality among newborns, and may result from impaired placental function during the first trimester of pregnancy1. Here we show that the risk of delivering a low-birth-weight baby at term after an uncomplicated pregnancy varies with maternal circulating concentrations of a placental protein, pregnancy-associated plasma protein-A (PAPP-A) in the first 10 weeks after conception. Poor fetal growth may therefore already have been determined by the time obstetric monitoring begins after completion of the first trimester.

Date: 2002
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DOI: 10.1038/417916a

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