RNA interference in adult mice

Anton P. McCaffrey, Leonard Meuse, Thu-Thao T. Pham, Douglas S. Conklin, Gregory J. Hannon and Mark A. Kay ()
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Anton P. McCaffrey: Stanford University School of Medicine
Leonard Meuse: Stanford University School of Medicine
Thu-Thao T. Pham: Stanford University School of Medicine
Douglas S. Conklin: Cold Spring Harbor Laboratory
Gregory J. Hannon: Cold Spring Harbor Laboratory
Mark A. Kay: Stanford University School of Medicine

Nature, 2002, vol. 418, issue 6893, 38-39

Abstract: Abstract RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from DNA templates. We also show the therapeutic potential of this technique by demonstrating effective targeting of a sequence from hepatitis C virus by RNA interference in vivo.

Date: 2002
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DOI: 10.1038/418038a

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