Sequence and analysis of chromosome 2 of Dictyostelium discoideum

Gernot Glöckner (), Ludwig Eichinger, Karol Szafranski, Justin A. Pachebat, Alan T. Bankier, Paul H. Dear, Rüdiger Lehmann, Cornelia Baumgart, Genís Parra, Josep F. Abril, Roderic Guigó, Kai Kumpf, Budi Tunggal, Edward Cox, Michael A. Quail, Matthias Platzer, André Rosenthal, Angelika A. Noegel (), Bart G. Barrell, Marie-Adèle Rajandream, Jeffrey G. Williams, Robert R. Kay, Adam Kuspa, Richard Gibbs, Richard Sucgang, Donna Muzny, Brian Desany, Kathy Zeng, Baoli Zhu, Pieter de Jong, Theodor Dingermann, Günther Gerisch, Peter Philippsen, Michael Schleicher, Stephan C. Schuster and Thomas Winckler
Additional contact information
Gernot Glöckner: IMB Jena, Department of Genome Analysis
Ludwig Eichinger: Center for Biochemistry, Medical Faculty, University of Cologne
Karol Szafranski: IMB Jena, Department of Genome Analysis
Justin A. Pachebat: Medical Research Council Laboratory of Molecular Biology, MRC Centre
Alan T. Bankier: Medical Research Council Laboratory of Molecular Biology, MRC Centre
Paul H. Dear: Medical Research Council Laboratory of Molecular Biology, MRC Centre
Rüdiger Lehmann: IMB Jena, Department of Genome Analysis
Cornelia Baumgart: IMB Jena, Department of Genome Analysis
Genís Parra: Grup de Recerca en Informatica Biomedica, Institut Municipal d'Inveastigació Mèdica, Universitat Pompeu Fabra, Centre de Regulació Genòmica
Josep F. Abril: Grup de Recerca en Informatica Biomedica, Institut Municipal d'Inveastigació Mèdica, Universitat Pompeu Fabra, Centre de Regulació Genòmica
Roderic Guigó: Grup de Recerca en Informatica Biomedica, Institut Municipal d'Inveastigació Mèdica, Universitat Pompeu Fabra, Centre de Regulació Genòmica
Kai Kumpf: IMB Jena, Department of Genome Analysis
Budi Tunggal: Center for Biochemistry, Medical Faculty, University of Cologne
Edward Cox: Princeton University
Michael A. Quail: The Sanger Institute, Wellcome Trust Genome Campus
Matthias Platzer: IMB Jena, Department of Genome Analysis
André Rosenthal: Friedrich Schiller Universität
Angelika A. Noegel: Center for Biochemistry, Medical Faculty, University of Cologne
Bart G. Barrell: The Sanger Institute, Wellcome Trust Genome Campus
Marie-Adèle Rajandream: The Sanger Institute, Wellcome Trust Genome Campus
Jeffrey G. Williams: University of Dundee, MSI/WTB Complex
Robert R. Kay: MRC Laboratory, of Molecular Biology
Adam Kuspa: Baylor College of Medicine
Richard Gibbs: Baylor College of Medicine
Richard Sucgang: Baylor College of Medicine
Donna Muzny: Baylor College of Medicine
Brian Desany: Baylor College of Medicine
Kathy Zeng: Children's Hospital Oakland – BACPAC Resources
Baoli Zhu: Children's Hospital Oakland – BACPAC Resources
Pieter de Jong: Children's Hospital Oakland – BACPAC Resources
Theodor Dingermann: Institut für Pharmazeutische Biologie, Universität Frankfurt (Biozentrum)
Günther Gerisch: Max-Planck-Institut für Biochemie
Peter Philippsen: Molecular Microbiology, Biozentrum der Universität
Michael Schleicher: A.-Butenandt-Institut/Zellbiologie, Ludwig-Maximilians-Universität
Stephan C. Schuster: Max-Planck-Institut für Entwicklungsbiologie
Thomas Winckler: Institut für Pharmazeutische Biologie, Universität Frankfurt (Biozentrum)

Nature, 2002, vol. 418, issue 6893, 79-85

Abstract: Abstract The genome of the lower eukaryote Dictyostelium discoideum comprises six chromosomes. Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of the genome. Despite an A + T content of nearly 80%, the chromosome codes for 2,799 predicted protein coding genes and 73 transfer RNA genes. This gene density, about 1 gene per 2.6 kilobases (kb), is surpassed only by Saccharomyces cerevisiae (one per 2 kb) and is similar to that of Schizosaccharomyces pombe (one per 2.5 kb)1,2. If we assume that the other chromosomes have a similar gene density, we can expect around 11,000 genes in the D. discoideum genome. A significant number of the genes show higher similarities to genes of vertebrates than to those of other fully sequenced eukaryotes1,2,3,4,5,6. This analysis strengthens the view that the evolutionary position of D. discoideum is located before the branching of metazoa and fungi but after the divergence of the plant kingdom7, placing it close to the base of metazoan evolution.

Date: 2002
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DOI: 10.1038/nature00847

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