RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow

Yuehua Jiang, Balkrishna N. Jahagirdar, R. Lee Reinhardt, Robert E. Schwartz, C. Dirk Keene, Xilma R. Ortiz-Gonzalez, Morayma Reyes, Todd Lenvik, Troy Lund, Mark Blackstad, Jingbo Du, Sara Aldrich, Aaron Lisberg, Walter C. Low, David A. Largaespada and Catherine M. Verfaillie ()
Additional contact information
Yuehua Jiang: Stem Cell Institute, University of Minnesota Medical School
Balkrishna N. Jahagirdar: Stem Cell Institute, University of Minnesota Medical School
R. Lee Reinhardt: University of Minnesota Medical School
Robert E. Schwartz: Stem Cell Institute, University of Minnesota Medical School
C. Dirk Keene: University of Minnesota Medical School
Xilma R. Ortiz-Gonzalez: University of Minnesota Medical School
Morayma Reyes: Stem Cell Institute, University of Minnesota Medical School
Todd Lenvik: Stem Cell Institute, University of Minnesota Medical School
Troy Lund: Stem Cell Institute, University of Minnesota Medical School
Mark Blackstad: Stem Cell Institute, University of Minnesota Medical School
Jingbo Du: Stem Cell Institute, University of Minnesota Medical School
Sara Aldrich: Stem Cell Institute, University of Minnesota Medical School
Aaron Lisberg: Stem Cell Institute, University of Minnesota Medical School
Walter C. Low: University of Minnesota Medical School
David A. Largaespada: University of Minnesota Medical School
Catherine M. Verfaillie: Stem Cell Institute, University of Minnesota Medical School

Nature, 2002, vol. 418, issue 6893, 41-49

Abstract: Abstract We report here that cells co-purifying with mesenchymal stem cells—termed here multipotent adult progenitor cells or MAPCs—differentiate, at the single cell level, not only into mesenchymal cells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro. When injected into an early blastocyst, single MAPCs contribute to most, if not all, somatic cell types. On transplantation into a non-irradiated host, MAPCs engraft and differentiate to the haematopoietic lineage, in addition to the epithelium of liver, lung and gut. Engraftment in the haematopoietic system as well as the gastrointestinal tract is increased when MAPCs are transplanted in a minimally irradiated host. As MAPCs proliferate extensively without obvious senescence or loss of differentiation potential, they may be an ideal cell source for therapy of inherited or degenerative diseases.

Date: 2002
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DOI: 10.1038/nature00870

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