Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease

Jong-Hoon Kim, Jonathan M. Auerbach, José A. Rodríguez-Gómez, Iván Velasco, Denise Gavin, Nadya Lumelsky, Sang-Hun Lee, John Nguyen, Rosario Sánchez-Pernaute, Krys Bankiewicz and Ron McKay ()
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Jong-Hoon Kim: National Institute of Neurological Disorders and Stroke, National Institute of Health
Jonathan M. Auerbach: NeuralStem, Inc.
José A. Rodríguez-Gómez: National Institute of Neurological Disorders and Stroke, National Institute of Health
Iván Velasco: National Institute of Neurological Disorders and Stroke, National Institute of Health
Denise Gavin: National Institute of Neurological Disorders and Stroke, National Institute of Health
Nadya Lumelsky: National Institute of Neurological Disorders and Stroke, National Institute of Health
Sang-Hun Lee: National Institute of Neurological Disorders and Stroke, National Institute of Health
John Nguyen: National Institute of Neurological Disorders and Stroke, National Institute of Health
Rosario Sánchez-Pernaute: National Institute of Neurological Disorders and Stroke, National Institute of Health
Krys Bankiewicz: National Institute of Neurological Disorders and Stroke, National Institute of Health
Ron McKay: National Institute of Neurological Disorders and Stroke, National Institute of Health

Nature, 2002, vol. 418, issue 6893, 50-56

Abstract: Abstract Parkinson's disease is a widespread condition caused by the loss of midbrain neurons that synthesize the neurotransmitter dopamine. Cells derived from the fetal midbrain can modify the course of the disease, but they are an inadequate source of dopamine-synthesizing neurons because their ability to generate these neurons is unstable. In contrast, embryonic stem (ES) cells proliferate extensively and can generate dopamine neurons. If ES cells are to become the basis for cell therapies, we must develop methods of enriching for the cell of interest and demonstrate that these cells show functions that will assist in treating the disease. Here we show that a highly enriched population of midbrain neural stem cells can be derived from mouse ES cells. The dopamine neurons generated by these stem cells show electrophysiological and behavioural properties expected of neurons from the midbrain. Our results encourage the use of ES cells in cell-replacement therapy for Parkinson's disease.

Date: 2002
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DOI: 10.1038/nature00900

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