The chemical repertoire of natural ribozymes

Jennifer A. Doudna () and Thomas R. Cech ()
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Jennifer A. Doudna: University of California
Thomas R. Cech: Howard Hughes Medical Institute

Nature, 2002, vol. 418, issue 6894, 222-228

Abstract: Abstract Although RNA is generally thought to be a passive genetic blueprint, some RNA molecules, called ribozymes, have intrinsic enzyme-like activity — they can catalyse chemical reactions in the complete absence of protein cofactors. In addition to the well-known small ribozymes that cleave phosphodiester bonds, we now know that RNA catalysts probably effect a number of key cellular reactions. This versatility has lent credence to the idea that RNA molecules may have been central to the early stages of life on Earth.

Date: 2002
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DOI: 10.1038/418222a

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