RNA interference

Gregory J. Hannon ()
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Gregory J. Hannon: Cold Spring Harbour Laboratory

Nature, 2002, vol. 418, issue 6894, 244-251

Abstract: Abstract A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNAi has been cultivated as a means to manipulate gene expression experimentally and to probe gene function on a whole-genome scale.

Date: 2002
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DOI: 10.1038/418244a

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