TRPV3 is a temperature-sensitive vanilloid receptor-like protein

G. D. Smith, M. J. Gunthorpe, R. E. Kelsell, P. D. Hayes, P. Reilly, P. Facer, J. E. Wright, J. C. Jerman, J.-P. Walhin, L. Ooi, J. Egerton, K. J. Charles, D. Smart, A. D. Randall, P. Anand and J. B. Davis ()
Additional contact information
G. D. Smith: Neurology-CEDD, GlaxoSmithKline
M. J. Gunthorpe: Neurology-CEDD, GlaxoSmithKline
R. E. Kelsell: Genetics Research, GlaxoSmithKline
P. D. Hayes: Genetics Research, GlaxoSmithKline
P. Reilly: Neurology-CEDD, GlaxoSmithKline
P. Facer: Imperial College, Hammersmith Hospital
J. E. Wright: Neurology-CEDD, GlaxoSmithKline
J. C. Jerman: Discovery Research, GlaxoSmithKline
J.-P. Walhin: Genetics Research, GlaxoSmithKline
L. Ooi: Neurology-CEDD, GlaxoSmithKline
J. Egerton: Neurology-CEDD, GlaxoSmithKline
K. J. Charles: Neurology-CEDD, GlaxoSmithKline
D. Smart: Neurology-CEDD, GlaxoSmithKline
A. D. Randall: Neurology-CEDD, GlaxoSmithKline
P. Anand: Imperial College, Hammersmith Hospital
J. B. Davis: Neurology-CEDD, GlaxoSmithKline

Nature, 2002, vol. 418, issue 6894, 186-190

Abstract: Abstract Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin1. Although VR1 gene disruption results in a loss of capsaicin responses, it has minimal effects on thermal nociception2,3. This and other experiments—such as those showing the existence of capsaicin-insensitive heat sensors in sensory neurons4—suggest the existence of thermosensitive receptors distinct from VR1. Here we identify a member of the vanilloid receptor/TRP gene family, vanilloid receptor-like protein 3 (VRL3, also known as TRPV3), which is heat-sensitive but capsaicin-insensitive. VRL3 is coded for by a 2,370-base-pair open reading frame, transcribed from a gene adjacent to VR1, and is structurally homologous to VR1. VRL3 responds to noxious heat with a threshold of about 39 °C and is co-expressed in dorsal root ganglion neurons with VR1. Furthermore, when heterologously expressed, VRL3 is able to associate with VR1 and may modulate its responses. Hence, not only is VRL3 a thermosensitive ion channel but it may represent an additional vanilloid receptor subunit involved in the formation of heteromeric vanilloid receptor channels.

Date: 2002
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DOI: 10.1038/nature00894

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