Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex

Travis H. Stracker, Christian T. Carson and Matthew D. Weitzman ()
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Travis H. Stracker: The Salk Institute for Biological Studies
Christian T. Carson: The Salk Institute for Biological Studies
Matthew D. Weitzman: The Salk Institute for Biological Studies

Nature, 2002, vol. 418, issue 6895, 348-352

Abstract: Abstract In mammalian cells, a conserved multiprotein complex of Mre11, Rad50 and NBS1 (also known as nibrin and p95) is important for double-strand break repair, meiotic recombination and telomere maintenance1,2,3,4. This complex forms nuclear foci and may be a sensor of double-strand breaks. In the absence of the early region E4, the double-stranded DNA genome of adenovirus is joined into concatemers too large to be packaged5,6. We have investigated the cellular proteins involved in this concatemer formation and how they are inactivated by E4 products during a wild-type infection. Here we show that concatemerization requires functional Mre11 and NBS1, and that these proteins are found at foci adjacent to viral replication centres. Infection with wild-type virus results in both reorganization and degradation of members of the Mre11–Rad50–NBS1 complex. These activities are mediated by three viral oncoproteins that prevent concatemerization. This targeting of cellular proteins involved in genomic stability suggests a mechanism for ‘hit-and-run’ transformation observed for these viral oncoproteins7.

Date: 2002
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DOI: 10.1038/nature00863

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