Screening inhibitors of anthrax lethal factor

Fiorella Tonello, Michela Seveso, Oriano Marin, Michèle Mock and Cesare Montecucco ()
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Fiorella Tonello: Istituto CNR Neuroscienze, Università di Padova
Michela Seveso: Istituto CNR Neuroscienze, Università di Padova
Oriano Marin: Università di Padova
Michèle Mock: Laboratoire de Génétique Moleculaire des Toxines (URA557, CNRS), Institut Pasteur
Cesare Montecucco: Istituto CNR Neuroscienze, Università di Padova

Nature, 2002, vol. 418, issue 6896, 386-386

Abstract: Abstract The disease anthrax is caused by lethal factor1, an enzyme component of the toxin produced by the spore-forming bacterium Bacillus anthracis2. Here we describe substrate molecules for this factor that offer a means for high-throughput screening of potential inhibitors for use in anthrax treatment3. Our assay should help to answer the urgent call for new and specific therapies4 to combat this pathogen after its recent emergence as a terrorist bioweapon.

Date: 2002
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DOI: 10.1038/418386a

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