Golgi biogenesis in Toxoplasma gondii

Laurence Pelletier, Charlene A. Stern, Marc Pypaert, David Sheff, Huân M. Ngô, Nitin Roper, Cynthia Y. He, Ke Hu, Derek Toomre, Isabelle Coppens, David S. Roos, Keith A. Joiner and Graham Warren ()
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Laurence Pelletier: Yale University School of Medicine
Charlene A. Stern: Harvard Medical School and The Dana-Farber Cancer Institute
Marc Pypaert: Yale University School of Medicine
David Sheff: Yale University School of Medicine
Huân M. Ngô: Yale University School of Medicine
Nitin Roper: Yale University School of Medicine
Cynthia Y. He: Yale University School of Medicine
Ke Hu: University of Pennsylvania
Derek Toomre: Yale University School of Medicine
Isabelle Coppens: Yale University School of Medicine
David S. Roos: University of Pennsylvania
Keith A. Joiner: Yale University School of Medicine
Graham Warren: Yale University School of Medicine

Nature, 2002, vol. 418, issue 6897, 548-552

Abstract: Abstract Two models have been put forward to explain the growth of new Golgi during the cell cycle. The first suggests that a new Golgi grows out of the endoplasmic reticulum by de novo synthesis1. The second suggests that a pre-existing Golgi is needed for the growth of a new one, that is, the Golgi is an autonomously replicating organelle2. To resolve this issue, we have exploited the simplicity of the apicomplexan parasite Toxoplasma gondii3, which has only a single Golgi stack4. Here we show, by using video fluorescence microscopy and three-dimensional reconstructions of serial thin sections, that the Golgi grows by a process of lateral extension followed by medial fission. Further fission leads to the inheritance by each daughter of a pair of Golgi structures, which then coalesce to re-form a single Golgi. Our results indicate that new Golgi grow by autonomous duplication and raise the possibility that the Golgi is a paired structure that is analogous to centrioles5.

Date: 2002
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DOI: 10.1038/nature00946

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