A physical map of the mouse genome

Simon G. Gregory, Mandeep Sekhon, Jacqueline Schein, Shaying Zhao, Kazutoyo Osoegawa, Carol E. Scott, Richard S. Evans, Paul W. Burridge, Tony V. Cox, Christopher A. Fox, Richard D. Hutton, Ian R. Mullenger, Kimbly J. Phillips, James Smith, Jim Stalker, Glen J. Threadgold, Ewan Birney, Kristine Wylie, Asif Chinwalla, John Wallis, LaDeana Hillier, Jason Carter, Tony Gaige, Sara Jaeger, Colin Kremitzki, Dan Layman, Jason Maas, Rebecca McGrane, Kelly Mead, Rebecca Walker, Steven Jones, Michael Smith, Jennifer Asano, Ian Bosdet, Susanna Chan, Suganthi Chittaranjan, Readman Chiu, Chris Fjell, Dan Fuhrmann, Noreen Girn, Catharine Gray, Ran Guin, Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Soo Sen Lee, Carrie Mathewson, Candice McLeavy, Steve Messervier, Steven Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Duane Smailus, Lorraine Spence, Jeff Stott, Sheryl Taylor, Wesley Terpstra, Miranda Tsai, Jill Vardy, Natasja Wye, George Yang, Sofiya Shatsman, Bola Ayodeji, Keita Geer, Getahun Tsegaye, Alla Shvartsbeyn, Elizabeth Gebregeorgis, Margaret Krol, Daniel Russell, Larry Overton, Joel A. Malek, Mike Holmes, Michael Heaney, Jyoti Shetty, Tamara Feldblyum, William C. Nierman, Joseph J. Catanese, Tim Hubbard, Robert H. Waterston, Jane Rogers, Pieter J. de Jong, Claire M. Fraser, Marco Marra, John D. McPherson and David R. Bentley ()
Additional contact information
Simon G. Gregory: The Wellcome Trust Sanger Institute
Mandeep Sekhon: Genome Sequencing Center, Washington University School of Medicine
Jacqueline Schein: Genome Sciences Centre, British Columbia Cancer Agency
Shaying Zhao: The Institute for Genomic Research
Kazutoyo Osoegawa: Children's Hospital Oakland Research Institute
Carol E. Scott: The Wellcome Trust Sanger Institute
Richard S. Evans: The Wellcome Trust Sanger Institute
Paul W. Burridge: The Wellcome Trust Sanger Institute
Tony V. Cox: The Wellcome Trust Sanger Institute
Christopher A. Fox: The Wellcome Trust Sanger Institute
Richard D. Hutton: The Wellcome Trust Sanger Institute
Ian R. Mullenger: The Wellcome Trust Sanger Institute
Kimbly J. Phillips: The Wellcome Trust Sanger Institute
James Smith: The Wellcome Trust Sanger Institute
Jim Stalker: The Wellcome Trust Sanger Institute
Glen J. Threadgold: The Wellcome Trust Sanger Institute
Ewan Birney: EMBL—European Bioinformatics Institute
Kristine Wylie: Genome Sequencing Center, Washington University School of Medicine
Asif Chinwalla: Genome Sequencing Center, Washington University School of Medicine
John Wallis: Genome Sequencing Center, Washington University School of Medicine
LaDeana Hillier: Genome Sequencing Center, Washington University School of Medicine
Jason Carter: Genome Sequencing Center, Washington University School of Medicine
Tony Gaige: Genome Sequencing Center, Washington University School of Medicine
Sara Jaeger: Genome Sequencing Center, Washington University School of Medicine
Colin Kremitzki: Genome Sequencing Center, Washington University School of Medicine
Dan Layman: Genome Sequencing Center, Washington University School of Medicine
Jason Maas: Genome Sequencing Center, Washington University School of Medicine
Rebecca McGrane: Genome Sequencing Center, Washington University School of Medicine
Kelly Mead: Genome Sequencing Center, Washington University School of Medicine
Rebecca Walker: Genome Sequencing Center, Washington University School of Medicine
Steven Jones: Genome Sciences Centre, British Columbia Cancer Agency
Michael Smith: Genome Sciences Centre, British Columbia Cancer Agency
Jennifer Asano: Genome Sciences Centre, British Columbia Cancer Agency
Ian Bosdet: Genome Sciences Centre, British Columbia Cancer Agency
Susanna Chan: Genome Sciences Centre, British Columbia Cancer Agency
Suganthi Chittaranjan: Genome Sciences Centre, British Columbia Cancer Agency
Readman Chiu: Genome Sciences Centre, British Columbia Cancer Agency
Chris Fjell: Genome Sciences Centre, British Columbia Cancer Agency
Dan Fuhrmann: Washington University
Noreen Girn: Genome Sciences Centre, British Columbia Cancer Agency
Catharine Gray: Genome Sciences Centre, British Columbia Cancer Agency
Ran Guin: Genome Sciences Centre, British Columbia Cancer Agency
Letticia Hsiao: Genome Sciences Centre, British Columbia Cancer Agency
Martin Krzywinski: Genome Sciences Centre, British Columbia Cancer Agency
Reta Kutsche: Genome Sciences Centre, British Columbia Cancer Agency
Soo Sen Lee: Genome Sciences Centre, British Columbia Cancer Agency
Carrie Mathewson: Genome Sciences Centre, British Columbia Cancer Agency
Candice McLeavy: Genome Sciences Centre, British Columbia Cancer Agency
Steve Messervier: Genome Sciences Centre, British Columbia Cancer Agency
Steven Ness: Genome Sciences Centre, British Columbia Cancer Agency
Pawan Pandoh: Genome Sciences Centre, British Columbia Cancer Agency
Anna-Liisa Prabhu: Genome Sciences Centre, British Columbia Cancer Agency
Parvaneh Saeedi: Genome Sciences Centre, British Columbia Cancer Agency
Duane Smailus: Genome Sciences Centre, British Columbia Cancer Agency
Lorraine Spence: Genome Sciences Centre, British Columbia Cancer Agency
Jeff Stott: Genome Sciences Centre, British Columbia Cancer Agency
Sheryl Taylor: Genome Sciences Centre, British Columbia Cancer Agency
Wesley Terpstra: Genome Sciences Centre, British Columbia Cancer Agency
Miranda Tsai: Genome Sciences Centre, British Columbia Cancer Agency
Jill Vardy: Genome Sciences Centre, British Columbia Cancer Agency
Natasja Wye: Genome Sciences Centre, British Columbia Cancer Agency
George Yang: Genome Sciences Centre, British Columbia Cancer Agency
Sofiya Shatsman: The Institute for Genomic Research
Bola Ayodeji: The Institute for Genomic Research
Keita Geer: The Institute for Genomic Research
Getahun Tsegaye: The Institute for Genomic Research
Alla Shvartsbeyn: The Institute for Genomic Research
Elizabeth Gebregeorgis: The Institute for Genomic Research
Margaret Krol: The Institute for Genomic Research
Daniel Russell: The Institute for Genomic Research
Larry Overton: The Institute for Genomic Research
Joel A. Malek: The Institute for Genomic Research
Mike Holmes: The Institute for Genomic Research
Michael Heaney: The Institute for Genomic Research
Jyoti Shetty: The Institute for Genomic Research
Tamara Feldblyum: The Institute for Genomic Research
William C. Nierman: The Institute for Genomic Research
Joseph J. Catanese: Children's Hospital Oakland Research Institute
Tim Hubbard: The Wellcome Trust Sanger Institute
Robert H. Waterston: Genome Sequencing Center, Washington University School of Medicine
Jane Rogers: The Wellcome Trust Sanger Institute
Pieter J. de Jong: Children's Hospital Oakland Research Institute
Claire M. Fraser: The Institute for Genomic Research
Marco Marra: Genome Sciences Centre, British Columbia Cancer Agency
John D. McPherson: Genome Sequencing Center, Washington University School of Medicine
David R. Bentley: The Wellcome Trust Sanger Institute

Nature, 2002, vol. 418, issue 6899, 743-750

Abstract: Abstract A physical map of a genome is an essential guide for navigation, allowing the location of any gene or other landmark in the chromosomal DNA. We have constructed a physical map of the mouse genome that contains 296 contigs of overlapping bacterial clones and 16,992 unique markers. The mouse contigs were aligned to the human genome sequence on the basis of 51,486 homology matches, thus enabling use of the conserved synteny (correspondence between chromosome blocks) of the two genomes to accelerate construction of the mouse map. The map provides a framework for assembly of whole-genome shotgun sequence data, and a tile path of clones for generation of the reference sequence. Definition of the human–mouse alignment at this level of resolution enables identification of a mouse clone that corresponds to almost any position in the human genome. The human sequence may be used to facilitate construction of other mammalian genome maps using the same strategy.

Date: 2002
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DOI: 10.1038/nature00957

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