A mitochondrial remnant in the microsporidian Trachipleistophora hominis

Bryony A. P. Williams, Robert P. Hirt, John M. Lucocq and T. Martin Embley ()
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Bryony A. P. Williams: The Natural History Museum
Robert P. Hirt: The Natural History Museum
John M. Lucocq: University of Dundee
T. Martin Embley: The Natural History Museum

Nature, 2002, vol. 418, issue 6900, 865-869

Abstract: Abstract Microsporidia are obligate intracellular parasites of several eukaryotes. They have a highly complex and unique infection apparatus but otherwise appear structurally simple1. Microsporidia are thought to lack typical eukaryotic organelles, such as mitochondria and peroxisomes. This has been interpreted as support for the hypothesis that these peculiar eukaryotes diverged before the mitochondrial endosymbiosis, which would make them one of the earliest offshoots in eukaryotic evolution2,3. But microsporidial nuclear genes that encode orthologues of typical mitochondrial heatshock Hsp70 proteins have been detected, which provides evidence for secondary loss of the organelle or endosymbiont4,5,6. In addition, gene trees and more sophisticated phylogenetic analyses have recovered microsporidia as the relatives of fungi, rather than as basal eukaryotes7,8,9. Here we show that a highly specific antibody raised against a Trachipleistophora hominis Hsp70 protein detects the presence, under light and electron microscopy, of numerous tiny (∼50 × 90 nm) organelles with double membranes in this human microsporidial parasite. The finding of relictual mitochondria in microsporidia provides further evidence of the reluctance of eukaryotes to lose the mitochondrial organelle, even when its canonical function of aerobic respiration has been apparently lost.

Date: 2002
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DOI: 10.1038/nature00949

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