Cognitive change and the APOE ɛ4 allele

Ian J. Deary (), Martha C. Whiteman, Alison Pattie, John M. Starr, Caroline Hayward, Alan F. Wright, Andrew Carothers and Lawrence J. Whalley
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Ian J. Deary: University of Edinburgh
Martha C. Whiteman: University of Edinburgh
Alison Pattie: University of Edinburgh
John M. Starr: Royal Victoria Hospital
Caroline Hayward: Medical Research Council Human Genetics Unit, Western General Hospital
Alan F. Wright: Medical Research Council Human Genetics Unit, Western General Hospital
Andrew Carothers: Medical Research Council Human Genetics Unit, Western General Hospital
Lawrence J. Whalley: University of Aberdeen, Clinical Research Centre, Royal Cornhill Hospital

Nature, 2002, vol. 418, issue 6901, 932-932

Abstract: Abstract There is a marked variation in whether people retain sufficient cognitive function to maintain their quality of life and independence in old age, even among those without dementia, so it would be valuable to identify the determinants of normal age-related cognitive change1,2. We have retested non-demented 80-year-olds who were participants in the Scottish Mental Survey of 1932, and find that the variation in their non-pathological cognitive change from age 11 to 80 is related to their apolipoprotein E (APOE) genotype. This effect of the APOE ɛ4 allele on normal cognitive ageing may be mediated by a mechanism that is at least partly independent of its predisposing effect towards Alzheimer's disease.

Date: 2002
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DOI: 10.1038/418932a

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