RGM is a repulsive guidance molecule for retinal axons

Philippe P. Monnier, Ana Sierra, Paolo Macchi, Lutz Deitinghoff, Jens S. Andersen, Matthias Mann, Manuela Flad, Martin R. Hornberger, Bernd Stahl, Friedrich Bonhoeffer and Bernhard K. Mueller ()
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Philippe P. Monnier: Migragen AG
Ana Sierra: Migragen AG
Paolo Macchi: Max-Planck-Institut für Entwicklungsbiologie
Lutz Deitinghoff: Migragen AG
Jens S. Andersen: University of Southern Denmark
Matthias Mann: University of Southern Denmark
Manuela Flad: DeveloGen AG
Martin R. Hornberger: Migragen AG
Bernd Stahl: Migragen AG
Friedrich Bonhoeffer: Max-Planck-Institut für Entwicklungsbiologie
Bernhard K. Mueller: Migragen AG

Nature, 2002, vol. 419, issue 6905, 392-395

Abstract: Abstract Axons rely on guidance cues to reach remote targets during nervous system development1. A well-studied model system for axon guidance is the retinotectal projection. The retina can be divided into halves; the nasal half, next to the nose, and the temporal half. A subset of retinal axons, those from the temporal half, is guided by repulsive cues expressed in a graded fashion in the optic tectum2,3, part of the midbrain. Here we report the cloning and functional characterization of a membrane-associated glycoprotein, which we call RGM (repulsive guidance molecule). This molecule shares no sequence homology with known guidance cues, and its messenger RNA is distributed in a gradient with increasing concentration from the anterior to posterior pole of the embryonic tectum. Recombinant RGM at low nanomolar concentration induces collapse of temporal but not of nasal growth cones and guides temporal retinal axons in vitro, demonstrating its repulsive and axon-specific guiding activity.

Date: 2002
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DOI: 10.1038/nature01041

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