Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases

Wun Chey Sin, Kurt Haas, Edward S. Ruthazer and Hollis T. Cline ()
Additional contact information
Wun Chey Sin: Cold Spring Harbor Laboratory
Kurt Haas: Cold Spring Harbor Laboratory
Edward S. Ruthazer: Cold Spring Harbor Laboratory
Hollis T. Cline: Cold Spring Harbor Laboratory

Nature, 2002, vol. 419, issue 6906, 475-480

Abstract: Abstract Previous studies suggest that neuronal activity may guide the development of synaptic connections in the central nervous system through mechanisms involving glutamate receptors and GTPase-dependent modulation of the actin cytoskeleton1,2,3,4,5,6,7. Here we demonstrate by in vivo time-lapse imaging of optic tectal cells in Xenopus laevis tadpoles that enhanced visual activity driven by a light stimulus promotes dendritic arbor growth. The stimulus-induced dendritic arbor growth requires glutamate-receptor-mediated synaptic transmission, decreased RhoA activity and increased Rac and Cdc42 activity. The results delineate a role for Rho GTPases in the structural plasticity driven by visual stimulation in vivo.

Date: 2002
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature00987 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:419:y:2002:i:6906:d:10.1038_nature00987

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature00987

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().