Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

Carlton, Jane M.; Angiuoli, Samuel V.; Suh, Bernard B.; Kooij, Taco W.; Pertea, Mihaela; Silva, Joana C.; Ermolaeva, Maria D.; Allen, Jonathan E.; Selengut, Jeremy D.; Koo, Hean L.; Peterson, Jeremy D.; Pop, Mihai; Kosack, Daniel S.; Shumway, Martin F.; Bidwell, Shelby L.; Shallom, Shamira J.; van Aken, Susan E.; Riedmuller, Steven B.; Feldblyum, Tamara V.; Cho, Jennifer K.; Quackenbush, John; Sedegah, Martha; Shoaibi, Azadeh; Cummings, Leda M.; Florens, Laurence; Yates, John R.; Raine, J. Dale; Sinden, Robert E.; Harris, Michael A.; Cunningham, Deirdre A.; Preiser, Peter R.; Bergman, Lawrence W.; Vaidya, Akhil B.; van Lin, Leo H.; Janse, Chris J.; Waters, Andrew P.; Smith, Hamilton O.; White, Owen R.; Salzberg, Steven L.; Venter, J. Craig; Fraser, Claire M.; Hoffman, Stephen L.; Gardner, Malcolm J.; Carucci, Daniel J.

Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

Jane M. Carlton (), Samuel V. Angiuoli, Bernard B. Suh, Taco W. Kooij, Mihaela Pertea, Joana C. Silva, Maria D. Ermolaeva, Jonathan E. Allen, Jeremy D. Selengut, Hean L. Koo, Jeremy D. Peterson, Mihai Pop, Daniel S. Kosack, Martin F. Shumway, Shelby L. Bidwell, Shamira J. Shallom, Susan E. van Aken, Steven B. Riedmuller, Tamara V. Feldblyum, Jennifer K. Cho, John Quackenbush, Martha Sedegah, Azadeh Shoaibi, Leda M. Cummings, Laurence Florens, John R. Yates, J. Dale Raine, Robert E. Sinden, Michael A. Harris, Deirdre A. Cunningham, Peter R. Preiser, Lawrence W. Bergman, Akhil B. Vaidya, Leo H. van Lin, Chris J. Janse, Andrew P. Waters, Hamilton O. Smith, Owen R. White, Steven L. Salzberg, J. Craig Venter, Claire M. Fraser, Stephen L. Hoffman, Malcolm J. Gardner and Daniel J. Carucci
Additional contact information
Jane M. Carlton: The Institute for Genomic Research
Samuel V. Angiuoli: The Institute for Genomic Research
Bernard B. Suh: The Institute for Genomic Research
Taco W. Kooij: Leiden University Medical Centre
Mihaela Pertea: The Institute for Genomic Research
Joana C. Silva: The Institute for Genomic Research
Maria D. Ermolaeva: The Institute for Genomic Research
Jonathan E. Allen: The Institute for Genomic Research
Jeremy D. Selengut: The Institute for Genomic Research
Hean L. Koo: The Institute for Genomic Research
Jeremy D. Peterson: The Institute for Genomic Research
Mihai Pop: The Institute for Genomic Research
Daniel S. Kosack: The Institute for Genomic Research
Martin F. Shumway: The Institute for Genomic Research
Shelby L. Bidwell: The Institute for Genomic Research
Shamira J. Shallom: The Institute for Genomic Research
Susan E. van Aken: The Institute for Genomic Research
Steven B. Riedmuller: The Institute for Genomic Research
Tamara V. Feldblyum: The Institute for Genomic Research
Jennifer K. Cho: The Institute for Genomic Research
John Quackenbush: The Institute for Genomic Research
Martha Sedegah: Naval Medical Research Center, Malaria Program (IDD)
Azadeh Shoaibi: The Institute for Genomic Research
Leda M. Cummings: The Institute for Genomic Research
Laurence Florens: The Scripps Research Institute
John R. Yates: The Scripps Research Institute
J. Dale Raine: Imperial College of Science, Technology & Medicine
Robert E. Sinden: Imperial College of Science, Technology & Medicine
Michael A. Harris: Celera Genomics
Deirdre A. Cunningham: National Institute for Medical Research
Peter R. Preiser: National Institute for Medical Research
Lawrence W. Bergman: Drexel University College of Medicine
Akhil B. Vaidya: Drexel University College of Medicine
Leo H. van Lin: Leiden University Medical Centre
Chris J. Janse: Leiden University Medical Centre
Andrew P. Waters: Leiden University Medical Centre
Hamilton O. Smith: Celera Genomics
Owen R. White: The Institute for Genomic Research
Steven L. Salzberg: The Institute for Genomic Research
J. Craig Venter: The Center for the Advancement of Genomics
Claire M. Fraser: The Institute for Genomic Research
Stephen L. Hoffman: Naval Medical Research Center, Malaria Program (IDD)
Malcolm J. Gardner: The Institute for Genomic Research
Daniel J. Carucci: Naval Medical Research Center, Malaria Program (IDD)

Nature, 2002, vol. 419, issue 6906, 512-519

Abstract: Abstract Species of malaria parasite that infect rodents have long been used as models for malaria disease research. Here we report the whole-genome shotgun sequence of one species, Plasmodium yoelii yoelii, and comparative studies with the genome of the human malaria parasite Plasmodium falciparum clone 3D7. A synteny map of 2,212 P. y. yoelii contiguous DNA sequences (contigs) aligned to 14 P. falciparum chromosomes reveals marked conservation of gene synteny within the body of each chromosome. Of about 5,300 P. falciparum genes, more than 3,300 P. y. yoelii orthologues of predominantly metabolic function were identified. Over 800 copies of a variant antigen gene located in subtelomeric regions were found. This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease.

Date: 2002
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DOI: 10.1038/nature01099

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