Sequence of Plasmodium falciparum chromosome 12

Richard W. Hyman (), Eula Fung, Aaron Conway, Omar Kurdi, Jennifer Mao, Molly Miranda, Brian Nakao, Don Rowley, Tomoaki Tamaki, Fawn Wang and Ronald W. Davis
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Richard W. Hyman: Stanford Genome Technology Center
Eula Fung: Stanford Genome Technology Center
Aaron Conway: Stanford Genome Technology Center
Omar Kurdi: Stanford Genome Technology Center
Jennifer Mao: Stanford Genome Technology Center
Molly Miranda: Stanford Genome Technology Center
Brian Nakao: Stanford Genome Technology Center
Don Rowley: Stanford Genome Technology Center
Tomoaki Tamaki: Stanford Genome Technology Center
Fawn Wang: Stanford Genome Technology Center
Ronald W. Davis: Stanford Genome Technology Center

Nature, 2002, vol. 419, issue 6906, 534-537

Abstract: Abstract The human malaria parasite Plasmodium falciparum is responsible for the death of more than a million people every year1. To stimulate basic research on the disease, and to promote the development of effective drugs and vaccines against the parasite, the complete genome of P. falciparum clone 3D7 has been sequenced, using a chromosome-by-chromosome shotgun strategy2,3,4. Here we report the nucleotide sequence of the third largest of the parasite's 14 chromosomes, chromosome 12, which comprises about 10% of the 23-megabase genome. As the most (A + T)-rich (80.6%) genome sequenced to date, the P. falciparum genome presented severe problems during the assembly of primary sequence reads. We discuss the methodology that yielded a finished and fully contiguous sequence for chromosome 12. The biological implications of the sequence data are more thoroughly discussed in an accompanying Article (ref. 3).

Date: 2002
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DOI: 10.1038/nature01102

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