A proteomic view of the Plasmodium falciparum life cycle

Laurence Florens, Michael P. Washburn, J. Dale Raine, Robert M. Anthony, Munira Grainger, J. David Haynes, J. Kathleen Moch, Nemone Muster, John B. Sacci, David L. Tabb, Adam A. Witney, Dirk Wolters, Yimin Wu, Malcolm J. Gardner, Anthony A. Holder, Robert E. Sinden, John R. Yates () and Daniel J. Carucci
Additional contact information
Laurence Florens: The Scripps Research Institute, SR-11
Michael P. Washburn: Syngenta Research & Technology
J. Dale Raine: Imperial College of Science, Technology & Medicine, Sir Alexander Fleming Building
Robert M. Anthony: Naval Medical Research Center, Malaria Program (IDD)
Munira Grainger: National Institute for Medical Research
J. David Haynes: Naval Medical Research Center, Malaria Program (IDD)
J. Kathleen Moch: Naval Medical Research Center, Malaria Program (IDD)
Nemone Muster: The Scripps Research Institute, SR-11
John B. Sacci: Naval Medical Research Center, Malaria Program (IDD)
David L. Tabb: The Scripps Research Institute, SR-11
Adam A. Witney: Naval Medical Research Center, Malaria Program (IDD)
Dirk Wolters: Syngenta Research & Technology
Yimin Wu: American Type Culture Collection
Malcolm J. Gardner: The Institute for Genomic Research
Anthony A. Holder: National Institute for Medical Research
Robert E. Sinden: Imperial College of Science, Technology & Medicine, Sir Alexander Fleming Building
John R. Yates: The Scripps Research Institute, SR-11
Daniel J. Carucci: Naval Medical Research Center, Malaria Program (IDD)

Nature, 2002, vol. 419, issue 6906, 520-526

Abstract: Abstract The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here, we applied a high-throughput proteomics approach to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite. We characterized four stages of the parasite life cycle (sporozoites, merozoites, trophozoites and gametocytes) by multidimensional protein identification technology. Functional profiling of over 2,400 proteins agreed with the physiology of each stage. Unexpectedly, the antigenically variant proteins of var and rif genes, defined as molecules on the surface of infected erythrocytes, were also largely expressed in sporozoites. The detection of chromosomal clusters encoding co-expressed proteins suggested a potential mechanism for controlling gene expression.

Date: 2002
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DOI: 10.1038/nature01107

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