An ATP-gated ion channel at the cell nucleus

Lucy Atkinson, Carol. J. Milligan, Noel J. Buckley and Jim Deuchars ()
Additional contact information
Lucy Atkinson: School of Biomedical Sciences, University of Leeds
Carol. J. Milligan: School of Biomedical Sciences, University of Leeds
Noel J. Buckley: School of Biochemistry and Molecular Biology, University of Leeds
Jim Deuchars: School of Biomedical Sciences, University of Leeds

Nature, 2002, vol. 420, issue 6911, 42-42

Abstract: Abstract Transcriptional activity inside the nucleus of eukaryotic cells is regulated by ions such as calcium that need to be transported across the nuclear membrane. Here we show that an ion channel spanning the nuclear envelope between the cytoplasm and the nucleus could be regulated by an ATP-binding receptor of the P2X7 subtype. Activation of this nuclear P2X7 receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression.

Date: 2002
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/420042a Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:420:y:2002:i:6911:d:10.1038_420042a

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/420042a

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().