Control, exploitation and tolerance of intracellular noise

Christopher V. Rao, Denise M. Wolf () and Adam P. Arkin
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Christopher V. Rao: Lawrence Berkeley National Laboratory, Howard Hughes Medical Institute
Denise M. Wolf: Lawrence Berkeley National Laboratory, Howard Hughes Medical Institute
Adam P. Arkin: Lawrence Berkeley National Laboratory, Howard Hughes Medical Institute

Nature, 2002, vol. 420, issue 6912, 231-237

Abstract: Abstract Noise has many roles in biological function, including generation of errors in DNA replication leading to mutation and evolution, noise-driven divergence of cell fates, noise-induced amplification of signals, and maintenance of the quantitative individuality of cells. Yet there is order to the behaviour and development of cells. They operate within strict parameters and in many cases this behaviour seems robust, implying that noise is largely filtered by the system. How can we explain the use, rejection and sensitivity to noise that is found in biological systems? An exploration of the sources and consequences of noise calls for the use of stochastic models.

Date: 2002
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DOI: 10.1038/nature01258

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