Chemical copying of connectivity

Lars Henning Eckardt, Kai Naumann, Wolf Matthias Pankau, Michael Rein, Markus Schweitzer, Norbert Windhab and Günter von Kiedrowski ()
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Lars Henning Eckardt: Lehrstuhl für Bioorganische Chemie, Ruhr-Universität Bochum
Kai Naumann: Lehrstuhl für Bioorganische Chemie, Ruhr-Universität Bochum
Wolf Matthias Pankau: Lehrstuhl für Bioorganische Chemie, Ruhr-Universität Bochum
Michael Rein: Lehrstuhl für Bioorganische Chemie, Ruhr-Universität Bochum
Markus Schweitzer: Nanogen Recognomics, Industriepark Hoechst
Norbert Windhab: Nanogen Recognomics, Industriepark Hoechst
Günter von Kiedrowski: Lehrstuhl für Bioorganische Chemie, Ruhr-Universität Bochum

Nature, 2002, vol. 420, issue 6913, 286-286

Abstract: Abstract Three-dimensional DNA nanoscaffolds such as supramolecular tetrahedra can self-assemble from tris-oligonucleotidyls — synthetic three-armed building blocks in which three identical or non-identical short DNA sequences are connected by a tris-linking backbone1,2. Here we show that the connectivity information contained in these building blocks can be copied by using template-directed tris-linking. This finding is a crucial step towards the replication of nanoarchitectures that are based on tris-oligonucleotidyls and to the realization of artificially self-replicating systems on a nanometre scale.

Date: 2002
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DOI: 10.1038/420286a

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