Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis

Stefano Pluchino, Angelo Quattrini, Elena Brambilla, Angela Gritti, Giuliana Salani, Giorgia Dina, Rossella Galli, Ubaldo Del Carro, Stefano Amadio, Alessandra Bergami, Roberto Furlan, Giancarlo Comi, Angelo L. Vescovi () and Gianvito Martino ()
Additional contact information
Stefano Pluchino: San Raffaele Hospital
Angelo Quattrini: San Raffaele Hospital
Elena Brambilla: San Raffaele Hospital
Angela Gritti: San Raffaele Hospital
Giuliana Salani: San Raffaele Hospital
Giorgia Dina: San Raffaele Hospital
Rossella Galli: San Raffaele Hospital
Ubaldo Del Carro: San Raffaele Hospital
Stefano Amadio: San Raffaele Hospital
Alessandra Bergami: San Raffaele Hospital
Roberto Furlan: San Raffaele Hospital
Giancarlo Comi: San Raffaele Hospital
Angelo L. Vescovi: San Raffaele Hospital
Gianvito Martino: San Raffaele Hospital

Nature, 2003, vol. 422, issue 6933, 688-694

Abstract: Abstract Widespread demyelination and axonal loss are the pathological hallmarks of multiple sclerosis. The multifocal nature of this chronic inflammatory disease of the central nervous system complicates cellular therapy and puts emphasis on both the donor cell origin and the route of cell transplantation. We established syngenic adult neural stem cell cultures and injected them into an animal model of multiple sclerosis—experimental autoimmune encephalomyelitis (EAE) in the mouse—either intravenously or intracerebroventricularly. In both cases, significant numbers of donor cells entered into demyelinating areas of the central nervous system and differentiated into mature brain cells. Within these areas, oligodendrocyte progenitors markedly increased, with many of them being of donor origin and actively remyelinating axons. Furthermore, a significant reduction of astrogliosis and a marked decrease in the extent of demyelination and axonal loss were observed in transplanted animals. The functional impairment caused by EAE was almost abolished in transplanted mice, both clinically and neurophysiologically. Thus, adult neural precursor cells promote multifocal remyelination and functional recovery after intravenous or intrathecal injection in a chronic model of multiple sclerosis.

Date: 2003
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DOI: 10.1038/nature01552

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