A new redox-cofactor vitamin for mammals

Takaoki Kasahara and Tadafumi Kato ()
Additional contact information
Takaoki Kasahara: Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN
Tadafumi Kato: Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN

Nature, 2003, vol. 422, issue 6934, 832-832

Abstract: Abstract Nicotinamides and flavins are essential cofactors in enzyme-catalysed reduction–oxidation (redox) reactions and are classified as vitamins because they must be supplied in the diet. Another redox cofactor, pyrroloquinoline quinone (PQQ), was first discovered in bacteria1 and is also likely to be important in mammals2,3, but the biochemical pathways in which it participates are unknown. Here we identify a PQQ-dependent dehydrogenase enzyme that is crucial for the degradation of the amino acid lysine in mice. PQQ is acting as a mammalian redox cofactor in this reaction, and therefore qualifies as a newcomer to the B group of vitamins.

Date: 2003
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/422832a Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:422:y:2003:i:6934:d:10.1038_422832a

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/422832a

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().