The genome sequence of the filamentous fungus Neurospora crassa

James E. Galagan (), Sarah E. Calvo, Katherine A. Borkovich, Eric U. Selker, Nick D. Read, David Jaffe, William FitzHugh, Li-Jun Ma, Serge Smirnov, Seth Purcell, Bushra Rehman, Timothy Elkins, Reinhard Engels, Shunguang Wang, Cydney B. Nielsen, Jonathan Butler, Matthew Endrizzi, Dayong Qui, Peter Ianakiev, Deborah Bell-Pedersen, Mary Anne Nelson, Margaret Werner-Washburne, Claude P. Selitrennikoff, John A. Kinsey, Edward L. Braun, Alex Zelter, Ulrich Schulte, Gregory O. Kothe, Gregory Jedd, Werner Mewes, Chuck Staben, Edward Marcotte, David Greenberg, Alice Roy, Karen Foley, Jerome Naylor, Nicole Stange-Thomann, Robert Barrett, Sante Gnerre, Michael Kamal, Manolis Kamvysselis, Evan Mauceli, Cord Bielke, Stephen Rudd, Dmitrij Frishman, Svetlana Krystofova, Carolyn Rasmussen, Robert L. Metzenberg, David D. Perkins, Scott Kroken, Carlo Cogoni, Giuseppe Macino, David Catcheside, Weixi Li, Robert J. Pratt, Stephen A. Osmani, Colin P. C. DeSouza, Louise Glass, Marc J. Orbach, J. Andrew Berglund, Rodger Voelker, Oded Yarden, Michael Plamann, Stephan Seiler, Jay Dunlap, Alan Radford, Rodolfo Aramayo, Donald O. Natvig, Lisa A. Alex, Gertrud Mannhaupt, Daniel J. Ebbole, Michael Freitag, Ian Paulsen, Matthew S. Sachs, Eric S. Lander, Chad Nusbaum and Bruce Birren ()
Additional contact information
James E. Galagan: Whitehead Institute Center for Genome Research
Sarah E. Calvo: Whitehead Institute Center for Genome Research
Katherine A. Borkovich: University of California
Eric U. Selker: University of Oregon
Nick D. Read: University of Edinburgh
David Jaffe: Whitehead Institute Center for Genome Research
William FitzHugh: Celera Genomics
Li-Jun Ma: Whitehead Institute Center for Genome Research
Serge Smirnov: Whitehead Institute Center for Genome Research
Seth Purcell: Whitehead Institute Center for Genome Research
Bushra Rehman: Whitehead Institute Center for Genome Research
Timothy Elkins: Whitehead Institute Center for Genome Research
Reinhard Engels: Whitehead Institute Center for Genome Research
Shunguang Wang: Whitehead Institute Center for Genome Research
Cydney B. Nielsen: Whitehead Institute Center for Genome Research
Jonathan Butler: Whitehead Institute Center for Genome Research
Matthew Endrizzi: Whitehead Institute Center for Genome Research
Dayong Qui: Whitehead Institute Center for Genome Research
Peter Ianakiev: Whitehead Institute Center for Genome Research
Deborah Bell-Pedersen: Texas A & M University
Mary Anne Nelson: University of New Mexico
Margaret Werner-Washburne: University of New Mexico
Claude P. Selitrennikoff: University of Colorado Health Sciences Center
John A. Kinsey: University of Kansas Medical School
Edward L. Braun: University of Florida
Alex Zelter: University of Edinburgh
Ulrich Schulte: Institute of Biochemistry, Heinrich Heine University
Gregory O. Kothe: University of Oregon
Gregory Jedd: Rockefeller University
Werner Mewes: Technical University of Munich, Wissenschaftzentrum Weihenstephan
Chuck Staben: University of Kentucky
Edward Marcotte: The University of Texas at Austin
David Greenberg: The Institute for Genomic Research
Alice Roy: Whitehead Institute Center for Genome Research
Karen Foley: Whitehead Institute Center for Genome Research
Jerome Naylor: Whitehead Institute Center for Genome Research
Nicole Stange-Thomann: Whitehead Institute Center for Genome Research
Robert Barrett: Whitehead Institute Center for Genome Research
Sante Gnerre: Whitehead Institute Center for Genome Research
Michael Kamal: Whitehead Institute Center for Genome Research
Manolis Kamvysselis: Whitehead Institute Center for Genome Research
Evan Mauceli: Whitehead Institute Center for Genome Research
Cord Bielke: Technical University of Munich, Wissenschaftzentrum Weihenstephan
Stephen Rudd: Institute for Bioinformatics (MIPS), GSF-National Research Center for Environment and Health
Dmitrij Frishman: Institute for Bioinformatics (MIPS), GSF-National Research Center for Environment and Health
Svetlana Krystofova: University of California
Carolyn Rasmussen: University of California
Robert L. Metzenberg: University of California
David D. Perkins: University of California
Scott Kroken: University of California
Carlo Cogoni: Universita' di Roma La Sapienza
Giuseppe Macino: Universita' di Roma La Sapienza
David Catcheside: Flinders University
Weixi Li: University of Kentucky
Robert J. Pratt: Texas A & M University
Stephen A. Osmani: The Ohio State University
Colin P. C. DeSouza: The Ohio State University
Louise Glass: University of California
Marc J. Orbach: University of Arizona
J. Andrew Berglund: University of Oregon
Rodger Voelker: University of Oregon
Oded Yarden: The Hebrew University of Jerusalem
Michael Plamann: University of Missouri-Kansas City
Stephan Seiler: University of Missouri-Kansas City
Jay Dunlap: Dartmouth Medical School
Alan Radford: Leeds University
Rodolfo Aramayo: Texas A & M University
Donald O. Natvig: University of New Mexico
Lisa A. Alex: California State Polytechnic University Pomona
Gertrud Mannhaupt: Technical University of Munich, Wissenschaftzentrum Weihenstephan
Daniel J. Ebbole: Texas A & M University
Michael Freitag: University of Oregon
Ian Paulsen: The Institute for Genomic Research
Matthew S. Sachs: Oregon Health and Science University
Eric S. Lander: Whitehead Institute Center for Genome Research
Chad Nusbaum: Whitehead Institute Center for Genome Research
Bruce Birren: Whitehead Institute Center for Genome Research

Nature, 2003, vol. 422, issue 6934, 859-868

Abstract: Abstract Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. The approximately 40-megabase genome encodes about 10,000 protein-coding genes—more than twice as many as in the fission yeast Schizosaccharomyces pombe and only about 25% fewer than in the fruitfly Drosophila melanogaster. Analysis of the gene set yields insights into unexpected aspects of Neurospora biology including the identification of genes potentially associated with red light photobiology, genes implicated in secondary metabolism, and important differences in Ca2+ signalling as compared with plants and animals. Neurospora possesses the widest array of genome defence mechanisms known for any eukaryotic organism, including a process unique to fungi called repeat-induced point mutation (RIP). Genome analysis suggests that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.

Date: 2003
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DOI: 10.1038/nature01554

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