Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing

Shuang-Xi Ren, Gang Fu, Xiu-Gao Jiang, Rong Zeng, You-Gang Miao, Hai Xu, Yi-Xuan Zhang, Hui Xiong, Gang Lu, Ling-Feng Lu, Hong-Quan Jiang, Jia Jia, Yue-Feng Tu, Ju-Xing Jiang, Wen-Yi Gu, Yue-Qing Zhang, Zhen Cai, Hai-Hui Sheng, Hai-Feng Yin, Yi Zhang, Gen-Feng Zhu, Ma Wan, Hong-Lei Huang, Zhen Qian, Sheng-Yue Wang, Wei Ma, Zhi-Jian Yao, Yan Shen, Bo-Qin Qiang, Qi-Chang Xia, Xiao-Kui Guo, Antoine Danchin, Isabelle Saint Girons, Ronald L. Somerville, Yu-Mei Wen, Man-Hua Shi, Zhu Chen, Jian-Guo Xu and Guo-Ping Zhao ()
Additional contact information
Shuang-Xi Ren: Chinese National Human Genome Center at Shanghai (CHGCS)
Gang Fu: Chinese National Human Genome Center at Shanghai (CHGCS)
Xiu-Gao Jiang: Chinese Center for Disease Control and Prevention (ICDC, China CDC)
Rong Zeng: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
You-Gang Miao: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Hai Xu: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Yi-Xuan Zhang: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Hui Xiong: Shanghai Second Medical University
Gang Lu: Chinese National Human Genome Center at Shanghai (CHGCS)
Ling-Feng Lu: Chinese National Human Genome Center at Shanghai (CHGCS)
Hong-Quan Jiang: Chinese National Human Genome Center at Shanghai (CHGCS)
Jia Jia: Chinese National Human Genome Center at Shanghai (CHGCS)
Yue-Feng Tu: Chinese National Human Genome Center at Shanghai (CHGCS)
Ju-Xing Jiang: Chinese National Human Genome Center, Beijing
Wen-Yi Gu: Chinese National Human Genome Center at Shanghai (CHGCS)
Yue-Qing Zhang: Chinese National Human Genome Center at Shanghai (CHGCS)
Zhen Cai: Chinese National Human Genome Center at Shanghai (CHGCS)
Hai-Hui Sheng: Chinese National Human Genome Center at Shanghai (CHGCS)
Hai-Feng Yin: Chinese National Human Genome Center at Shanghai (CHGCS)
Yi Zhang: Chinese National Human Genome Center at Shanghai (CHGCS)
Gen-Feng Zhu: Chinese National Human Genome Center at Shanghai (CHGCS)
Ma Wan: Chinese Center for Disease Control and Prevention (ICDC, China CDC)
Hong-Lei Huang: Chinese Center for Disease Control and Prevention (ICDC, China CDC)
Zhen Qian: Chinese National Human Genome Center at Shanghai (CHGCS)
Sheng-Yue Wang: Chinese National Human Genome Center at Shanghai (CHGCS)
Wei Ma: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Zhi-Jian Yao: Chinese National Human Genome Center, Beijing
Yan Shen: Chinese National Human Genome Center, Beijing
Bo-Qin Qiang: Chinese National Human Genome Center, Beijing
Qi-Chang Xia: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Xiao-Kui Guo: Shanghai Second Medical University
Antoine Danchin: HKU-Pasteur Research Centre
Isabelle Saint Girons: Unité de Bactériologie Moléculaire et Médicale, Institut Pasteur
Ronald L. Somerville: Purdue University
Yu-Mei Wen: Fudan University
Man-Hua Shi: Chinese Center for Disease Control and Prevention (ICDC, China CDC)
Zhu Chen: Chinese National Human Genome Center at Shanghai (CHGCS)
Jian-Guo Xu: Chinese Center for Disease Control and Prevention (ICDC, China CDC)
Guo-Ping Zhao: Chinese National Human Genome Center at Shanghai (CHGCS)

Nature, 2003, vol. 422, issue 6934, 888-893

Abstract: Abstract Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pulmonary haemorrhages, including fatal sudden haemoptysis, can occur1. Here we report the complete genomic sequence of a representative virulent serovar type strain (Lai)2 of Leptospira interrogans serogroup Icterohaemorrhagiae consisting of a 4.33-megabase large chromosome and a 359-kilobase small chromosome, with a total of 4,768 predicted genes. In terms of the genetic determinants of physiological characteristics, the facultatively parasitic L. interrogans differs extensively from two other strictly parasitic pathogenic spirochaetes, Treponema pallidum3 and Borrelia burgdorferi4, although similarities exist in the genes that govern their unique morphological features. A comprehensive analysis of the L. interrogans genes for chemotaxis/motility and lipopolysaccharide synthesis provides a basis for in-depth studies of virulence and pathogenesis. The discovery of a series of genes possibly related to adhesion, invasion and the haematological changes that characterize leptospirosis has provided clues about how an environmental organism might evolve into an important human pathogen.

Date: 2003
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature01597 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:422:y:2003:i:6934:d:10.1038_nature01597

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature01597

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().