Ligand–receptor binding revealed by the TNF family member TALL-1

Yingfang Liu, Xia Hong, John Kappler, Ling Jiang, Rongguang Zhang, Liangguo Xu, Cheol-Ho Pan, Wesley E. Martin, Robert C. Murphy, Hong-Bing Shu, Shaodong Dai and Gongyi Zhang ()
Additional contact information
John Kappler: Howard Hughes Medical Institute
Rongguang Zhang: Structural Biology Section, Argonne National Laboratory
Hong-Bing Shu: Peking University
Gongyi Zhang: Howard Hughes Medical Institute

Nature, 2003, vol. 423, issue 6935, 49-56

Abstract: Abstract The tumour necrosis factor (TNF) ligand TALL-1 and its cognate receptors, BCMA, TACI and BAFF-R, were recently identified as members of the TNF superfamily, which are essential factors contributing to B-cell maturation. The functional, soluble fragment of TALL-1 (sTALL-1) forms a virus-like assembly for its proper function. Here we determine the crystal structures of sTALL-1 complexed with the extracellular domains of BCMA and BAFF-R at 2.6 and 2.5 Å, respectively. The single cysteine-rich domain of BCMA and BAFF-R both have saddle-like architectures, which sit on the horseback-like surface formed by four coil regions on each individual sTALL-1 monomer. Three novel structural modules, D2, X2 and N, were revealed from the current structures. Sequence alignments, structural modelling and mutagenesis revealed that one disulphide bridge in BAFF-R is critical for determining the binding specificity of the extracellular domain eBAFF-R to TALL-1 instead of APRIL, a closely related ligand of TALL-1, which was confirmed by binding experiments in vitro.

Date: 2003
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature01543 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:423:y:2003:i:6935:d:10.1038_nature01543

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature01543

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().