Insecticide resistance in mosquito vectors

Mylène Weill (), Georges Lutfalla, Knud Mogensen, Fabrice Chandre, Arnaud Berthomieu, Claire Berticat, Nicole Pasteur, Alexandre Philips, Philippe Fort and Michel Raymond
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Mylène Weill: Institut des Sciences de l'Évolution (UMR 5554), CC 065, Université Montpellier II
Georges Lutfalla: Défenses Antivirales et Tumorales (UMR 5124)
Knud Mogensen: Défenses Antivirales et Tumorales (UMR 5124)
Fabrice Chandre: IRD/LIN, BP 64501
Arnaud Berthomieu: Institut des Sciences de l'Évolution (UMR 5554), CC 065, Université Montpellier II
Claire Berticat: Institut des Sciences de l'Évolution (UMR 5554), CC 065, Université Montpellier II
Nicole Pasteur: Institut des Sciences de l'Évolution (UMR 5554), CC 065, Université Montpellier II
Alexandre Philips: Centre de Recherche en Biochimie des Macromolécules (UPR1086), CNRS
Philippe Fort: Centre de Recherche en Biochimie des Macromolécules (UPR1086), CNRS
Michel Raymond: Institut des Sciences de l'Évolution (UMR 5554), CC 065, Université Montpellier II

Nature, 2003, vol. 423, issue 6936, 136-137

Abstract: Abstract Resistance to insecticides among mosquitoes that act as vectors for malaria (Anopheles gambiae) and West Nile virus (Culex pipiens) emerged more than 25 years ago in Africa, America and Europe; this resistance is frequently due to a loss of sensitivity of the insect's acetylcholinesterase enzyme to organophosphates and carbamates1. Here we show that this insensitivity results from a single amino-acid substitution in the enzyme, which we found in ten highly resistant strains of C. pipiens from tropical (Africa and Caribbean) and temperate (Europe) areas, as well as in one resistant African strain of A. gambiae. Our identification of this mutation may pave the way for designing new insecticides.

Date: 2003
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DOI: 10.1038/423136b

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