BSE in sheep bred for resistance to infection

Fiona Houston (), Wilfred Goldmann, Angela Chong, Martin Jeffrey, Lorenzo González, James Foster, David Parnham and Nora Hunter
Additional contact information
Fiona Houston: Institute for Animal Health, Compton
Wilfred Goldmann: IAH Neuropathogenesis Unit
Angela Chong: IAH Neuropathogenesis Unit
Martin Jeffrey: Veterinary Laboratories Agency Lasswade, Pentlands Science Park
Lorenzo González: Veterinary Laboratories Agency Lasswade, Pentlands Science Park
James Foster: IAH Neuropathogenesis Unit
David Parnham: IAH Neuropathogenesis Unit
Nora Hunter: IAH Neuropathogenesis Unit

Nature, 2003, vol. 423, issue 6939, 498-498

Abstract: Abstract Selective breeding for disease-resistant genotypes is being pursued as a means of eradicating scrapie (and bovine spongiform encephalopathy (BSE), if it is present) from sheep flocks. Here we show that the genotype associated with the highest resistance can still be infected with BSE by intracerebral inoculation. Although the relevance of this finding to sheep exposed to natural infection remains to be determined, it may have important implications for disease-eradication strategies.

Date: 2003
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DOI: 10.1038/423498a

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