A TRPV family ion channel required for hearing in Drosophila

Janghwan Kim, Yun Doo Chung, Dae-young Park, SooKyung Choi, Dong Wook Shin, Heun Soh, Hye Won Lee, Wonseok Son, Jeongbin Yim, Chul-Seung Park, Maurice J. Kernan and Changsoo Kim ()
Additional contact information
Janghwan Kim: Hanwha Chemical Co. R&D Center
Yun Doo Chung: State University of New York at Stony Brook
Dae-young Park: Hanwha Chemical Co. R&D Center
SooKyung Choi: Hanwha Chemical Co. R&D Center
Dong Wook Shin: Hanwha Chemical Co. R&D Center
Heun Soh: K-JIST
Hye Won Lee: Hanwha Chemical Co. R&D Center
Wonseok Son: Hanwha Chemical Co. R&D Center
Jeongbin Yim: Seoul National University
Chul-Seung Park: K-JIST
Maurice J. Kernan: State University of New York at Stony Brook
Changsoo Kim: Hanwha Chemical Co. R&D Center

Nature, 2003, vol. 424, issue 6944, 81-84

Abstract: Abstract The many types of insect ear share a common sensory element, the chordotonal organ, in which sound-induced antennal or tympanal vibrations are transmitted to ciliated sensory neurons and transduced to receptor potentials1,2. However, the molecular identity of the transducing ion channels in chordotonal neurons, or in any auditory system, is still unknown3,4. Drosophila that are mutant for NOMPC, a transient receptor potential (TRP) superfamily ion channel, lack receptor potentials and currents in tactile bristles5,6 but retain most of the antennal sound-evoked response7, suggesting that a different channel is the primary transducer in chordotonal organs. Here we describe the Drosophila Nanchung (Nan) protein, an ion channel subunit similar to vanilloid-receptor-related (TRPV) channels of the TRP superfamily. Nan mediates hypo-osmotically activated calcium influx and cation currents in cultured cells. It is expressed in vivo exclusively in chordotonal neurons and is localized to their sensory cilia. Antennal sound-evoked potentials are completely absent in mutants lacking Nan, showing that it is an essential component of the chordotonal mechanotransducer.

Date: 2003
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DOI: 10.1038/nature01733

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