Transcription regulation and animal diversity

Michael Levine () and Robert Tjian ()
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Michael Levine: Center for Integrative Genomics
Robert Tjian: Center for Integrative Genomics

Nature, 2003, vol. 424, issue 6945, 147-151

Abstract: Abstract Whole-genome sequence assemblies are now available for seven different animals, including nematode worms, mice and humans. Comparative genome analyses reveal a surprising constancy in genetic content: vertebrate genomes have only about twice the number of genes that invertebrate genomes have, and the increase is primarily due to the duplication of existing genes rather than the invention of new ones. How, then, has evolutionary diversity arisen? Emerging evidence suggests that organismal complexity arises from progressively more elaborate regulation of gene expression.

Date: 2003
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DOI: 10.1038/nature01763

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