Bone adaptation requires oestrogen receptor-α

Karla Lee, Helen Jessop, Rosemary Suswillo, Gul Zaman and Lance Lanyon ()
Additional contact information
Karla Lee: The Royal Veterinary College
Helen Jessop: The Royal Veterinary College
Rosemary Suswillo: The Royal Veterinary College
Gul Zaman: The Royal Veterinary College
Lance Lanyon: The Royal Veterinary College

Nature, 2003, vol. 424, issue 6947, 389-389

Abstract: Abstract The strain imposed by mechanical loading on bone tissue normally stimulates a response by bone cells that results in an adjustment of bone architecture that enables the bone to withstand reasonable loads. But it is unclear why this process should become less effective in some 50 per cent of postmenopausal women, who suffer fractures as a result1. Here we show that bone in vivo undergoes an adaptive response to loading that is less effective in the absence of the α-form of the oestrogen receptor (ER-α) and that osteoblast-like cells require ER-α to proliferate in response to mechanical strain in vitro. As ER-α expression in osteoblasts and osteocytes depends on oestrogen concentration2,3,4,5, a failure to maintain bone strength after the menopause might be due to a reduction in the activity of ER-α in bone cells, thereby limiting their anabolic response to mechanical loading and allowing a loss of bone tissue comparable to that associated with disuse.

Date: 2003
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/424389a Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:424:y:2003:i:6947:d:10.1038_424389a

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/424389a

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().