Cell survival and a Gadd45-factor deficiency

Arshad Amanullah (), Naiyer Azam, Arthur Balliet, Christine Hollander, Barbara Hoffman, Albert Fornace and Dan Liebermann
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Arshad Amanullah: Temple University School of Medicine
Naiyer Azam: Temple University School of Medicine
Arthur Balliet: Temple University School of Medicine
Christine Hollander: Gene Response Section, Center for Cancer Research, National Cancer Institute, NIH
Barbara Hoffman: Temple University School of Medicine
Albert Fornace: Gene Response Section, Center for Cancer Research, National Cancer Institute, NIH
Dan Liebermann: Temple University School of Medicine

Nature, 2003, vol. 424, issue 6950, 741-741

Abstract: Abstract Tumour-necrosis factor-α (TNF-α) is an important protein that regulates inflammation, immunity, cell survival and cell death in response to infection or chronic stress1,2,3,4,5. De Smaele et al. report that the gene encoding an inducible cellular factor, Gadd45β (for 'growth arrest and DNA damage'), is essential for promoting TNF-α-mediated cell survival6. However, we show here that neither TNF-α signalling nor cell survival is affected in mice lacking gadd45β, a fact which demonstrates that genes other than gadd45β (refs 5, 7) might regulate cell survival in response to TNF-α.

Date: 2003
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DOI: 10.1038/424741b

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