Control of leaf morphogenesis by microRNAs

Javier F. Palatnik, Edwards Allen, Xuelin Wu, Carla Schommer, Rebecca Schwab, James C. Carrington () and Detlef Weigel ()
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Javier F. Palatnik: Max Planck Institute for Developmental Biology
Edwards Allen: Oregon State University
Xuelin Wu: The Salk Institute for Biological Studies
Carla Schommer: Max Planck Institute for Developmental Biology
Rebecca Schwab: Max Planck Institute for Developmental Biology
James C. Carrington: Oregon State University
Detlef Weigel: Max Planck Institute for Developmental Biology

Nature, 2003, vol. 425, issue 6955, 257-263

Abstract: Abstract Plants with altered microRNA metabolism have pleiotropic developmental defects, but direct evidence for microRNAs regulating specific aspects of plant morphogenesis has been lacking. In a genetic screen, we identified the JAW locus, which produces a microRNA that can guide messenger RNA cleavage of several TCP genes controlling leaf development. MicroRNA-guided cleavage of TCP4 mRNA is necessary to prevent aberrant activity of the TCP4 gene expressed from its native promoter. In addition, overexpression of wild-type and microRNA-resistant TCP variants demonstrates that mRNA cleavage is largely sufficient to restrict TCP function to its normal domain of activity. TCP genes with microRNA target sequences are found in a wide range of species, indicating that microRNA-mediated control of leaf morphogenesis is conserved in plants with very different leaf forms.

Date: 2003
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DOI: 10.1038/nature01958

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