Phagosomes are competent organelles for antigen cross-presentation

Mathieu Houde, Sylvie Bertholet, Etienne Gagnon, Sylvain Brunet, Guillaume Goyette, Annie Laplante, Michael F. Princiotta, Pierre Thibault, David Sacks and Michel Desjardins ()
Additional contact information
Mathieu Houde: Université de Montréal, C.P.6128, Succ centre-ville
Sylvie Bertholet: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Etienne Gagnon: Université de Montréal, C.P.6128, Succ centre-ville
Sylvain Brunet: Université de Montréal, C.P.6128, Succ centre-ville
Guillaume Goyette: Université de Montréal, C.P.6128, Succ centre-ville
Annie Laplante: Université de Montréal, C.P.6128, Succ centre-ville
Michael F. Princiotta: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Pierre Thibault: Caprion Pharmaceuticals Inc.
David Sacks: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Michel Desjardins: Université de Montréal, C.P.6128, Succ centre-ville

Nature, 2003, vol. 425, issue 6956, 402-406

Abstract: Abstract The ability to process microbial antigens and present them at the surface of cells is an important aspect of our innate ability to clear infections. It is generally accepted that antigens in the cytoplasm are loaded in the endoplasmic reticulum and presented at the cell surface on major histocompatibility complex (MHC) class I molecules, whereas peptides present in endo/phagocytic compartments are presented on MHC class II molecules1,2. Despite the apparent segregation of the class I and class II pathways, antigens from intracellular pathogens including mycobacteria, Escherichia coli, Salmonella typhimurium, Brucella abortus and Leishmania, have been shown to elicit an MHC class-I-dependent CD8+ T-cell response3,4,5,6,7, a process referred to as cross-presentation2. The cellular mechanisms allowing the cross-presentation pathway are poorly understood. Here we show that phagosomes display the elements and properties needed to be self-sufficient for the cross-presentation of exogenous antigens, a newly ascribed function linked to phagocytosis mediated by the endoplasmic reticulum.

Date: 2003
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature01912 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:425:y:2003:i:6956:d:10.1038_nature01912

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature01912

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().