Regulation of neuroblast competence in Drosophila

Bret J. Pearson and Chris Q. Doe ()
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Bret J. Pearson: University of Oregon 1254
Chris Q. Doe: University of Oregon 1254

Nature, 2003, vol. 425, issue 6958, 624-628

Abstract: Abstract Individual neural progenitors generate different cell types in a reproducible order in the retina1,2,3, cerebral cortex4,5,6 and probably in the spinal cord7. It is unknown how neural progenitors change over time to generate different cell types. It has been proposed that progenitors undergo progressive restriction8 or transit through distinct competence states9,10; however, the underlying molecular mechanisms remain unclear. Here we investigate neural progenitor competence and temporal identity using an in vivo genetic system—Drosophila neuroblasts—where the Hunchback transcription factor is necessary and sufficient to specify early-born cell types11. We show that neuroblasts gradually lose competence to generate early-born fates in response to Hunchback, similar to progressive restriction models8, and that competence to acquire early-born fates is present in mitotic precursors but is lost in post-mitotic neurons. These results match those observed in vertebrate systems, and establish Drosophila neuroblasts as a model system for the molecular genetic analysis of neural progenitor competence and plasticity.

Date: 2003
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DOI: 10.1038/nature01910

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