Genome-scale approaches to resolving incongruence in molecular phylogenies

Antonis Rokas, Barry L. Williams, Nicole King and Sean B. Carroll ()
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Antonis Rokas: University of Wisconsin-Madison
Barry L. Williams: University of Wisconsin-Madison
Nicole King: University of Wisconsin-Madison
Sean B. Carroll: University of Wisconsin-Madison

Nature, 2003, vol. 425, issue 6960, 798-804

Abstract: Abstract One of the most pervasive challenges in molecular phylogenetics is the incongruence between phylogenies obtained using different data sets, such as individual genes. To systematically investigate the degree of incongruence, and potential methods for resolving it, we screened the genome sequences of eight yeast species and selected 106 widely distributed orthologous genes for phylogenetic analyses, singly and by concatenation. Our results suggest that data sets consisting of single or a small number of concatenated genes have a significant probability of supporting conflicting topologies. By contrast, analyses of the entire data set of concatenated genes yielded a single, fully resolved species tree with maximum support. Comparable results were obtained with a concatenation of a minimum of 20 genes; substantially more genes than commonly used but a small fraction of any genome. These results have important implications for resolving branches of the tree of life.

Date: 2003
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DOI: 10.1038/nature02053

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