Independent rate and temporal coding in hippocampal pyramidal cells

John Huxter, Neil Burgess and John O'Keefe ()
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John Huxter: University College London
Neil Burgess: University College London
John O'Keefe: University College London

Nature, 2003, vol. 425, issue 6960, 828-832

Abstract: Abstract In the brain, hippocampal pyramidal cells use temporal1 as well as rate2 coding to signal spatial aspects of the animal's environment or behaviour. The temporal code takes the form of a phase relationship to the concurrent cycle of the hippocampal electroencephalogram theta rhythm1. These two codes could each represent a different variable3,4. However, this requires the rate and phase to vary independently, in contrast to recent suggestions5,6 that they are tightly coupled, both reflecting the amplitude of the cell's input. Here we show that the time of firing and firing rate are dissociable, and can represent two independent variables: respectively the animal's location within the place field, and its speed of movement through the field. Independent encoding of location together with actions and stimuli occurring there may help to explain the dual roles of the hippocampus in spatial and episodic memory7,8, or may indicate a more general role of the hippocampus in relational/declarative memory9,10.

Date: 2003
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DOI: 10.1038/nature02058

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