Influence of TOR kinase on lifespan in C. elegans

Tibor Vellai, Krisztina Takacs-Vellai, Yue Zhang, Attila L. Kovacs, László Orosz and Fritz Müller ()
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Tibor Vellai: University of Fribourg
Krisztina Takacs-Vellai: University of Fribourg
Yue Zhang: University of Fribourg
Attila L. Kovacs: Eötvös Loránd University
László Orosz: Eötvös Loránd University
Fritz Müller: University of Fribourg

Nature, 2003, vol. 426, issue 6967, 620-620

Abstract: Abstract The group of enzymes known as TOR (for 'target of rapamycin') kinases regulates cell growth and proliferation in response to nutrients and hormone-dependent mitogenic signals1,2. Here we show that TOR deficiency in the nematode Caenorhabditis elegans more than doubles its natural lifespan. This new function for TOR signalling in ageing control may represent a link between nutrition, metabolism and longevity.

Date: 2003
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DOI: 10.1038/426620a

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