Protein degradation and protection against misfolded or damaged proteins

Alfred L. Goldberg ()
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Alfred L. Goldberg: Harvard Medical School

Nature, 2003, vol. 426, issue 6968, 895-899

Abstract: Abstract The ultimate mechanism that cells use to ensure the quality of intracellular proteins is the selective destruction of misfolded or damaged polypeptides. In eukaryotic cells, the large ATP-dependent proteolytic machine, the 26S proteasome, prevents the accumulation of non-functional, potentially toxic proteins. This process is of particular importance in protecting cells against harsh conditions (for example, heat shock or oxidative stress) and in a variety of diseases (for example, cystic fibrosis and the major neurodegenerative diseases). A full understanding of the pathogenesis of the protein-folding diseases will require greater knowledge of how misfolded proteins are recognized and selectively degraded.

Date: 2003
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DOI: 10.1038/nature02263

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