Therapeutic approaches to protein-misfolding diseases

Fred E. Cohen () and Jeffery W. Kelly ()
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Fred E. Cohen: University of California at San Francisco
Jeffery W. Kelly: The Scripps Research Institute

Nature, 2003, vol. 426, issue 6968, 905-909

Abstract: Abstract Several sporadic and genetic diseases are caused by protein misfolding. These include cystic fibrosis and other devastating diseases of childhood as well as Alzheimer's, Parkinson's and other debilitating maladies of the elderly. A unified view of the molecular and cellular pathogenesis of these conditions has led to the search for chemical chaperones that can slow, arrest or revert disease progression. Molecules are now emerging that link our biophysical insights with our therapeutic aspirations.

Date: 2003
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DOI: 10.1038/nature02265

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